Tazarotene

Product Name:Tazarotene
Synonyms:Tazarotene 99% Min SynonyMs Ethyl 6-[2-(4,4-diMethylthiochroMan-6-yl)ethynyl]pyridine-3-carboxylate;Avage;6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinate;Tazarotene, >=98%;3-pyridinecarboxylicacid,6-((3,4-dihydro-4,4-dimethyl-2h-1-benzothiopyran-6-y;agn190168;ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate
CAS:118292-40-3
MF:C21H21NO2S
MW:351.46
EINECS:601-516-4
Product Categories:Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Retinoids;Sulfur & Selenium Compounds;Heterocycles;API;Tazorac, Avage, Zora
Melting point:95-98°C
storage temp.:Store at +4°C Room Temperature
solubility:DMSO: >15mg/mL
Density:1.22 g/cm3
Boiling Point:499.8ºC at 760 mmHg
Flash Point:256.1ºC
Refractive Index:1.624
Vapor Pressure:4.03E-10mmHg at 25°C
Appearance:White Solid powder
Purity:99%
Grade Standard:Medicine Grade
Package: Package:100g,500g,1KG,10KG,100KG 1kg/Alu bag or 25kg/Drum
Place of Origin:China
Description:Tazarotene belongs to a third generation prescription topical retinoid. It is marketed in different forms including cream (brand name: Avage), foam (brand name: Fabuir) and gel (brand name: Tazorac). It is mainly used for the treatment of psoriasis, acne, and sun damaged skin. The detailed mechanisms of action of Tazarotene are still unclear. It is converted to its active form, the cognate carboxylic acid of tazarotene (AGN 190299) in vivo through rapid de-esterification in animals and man. AGN 190299 is capable of binding to all the three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ with relative selectivity for RARβ, and RARγ. This process may further modify gene expression. However, it is unclear whether this is related to its mode of action. Common side effects associated with it include worsening of acne, desquamation, burning/stinging, erythema and pruritus increased sensitivity to sunlight, dry skin, itchiness, redness, skin pain rash and skin discoloration. In most cases, these side effects are mild and can remarkable decrease after the first 2–4 weeks. Tazarotene should not be used in the following cases: patients are allergic to it; patients are pregnant; patients have a sunburn; patients are taking photo-sensitive drugs such as thiazides and tetracycline.
Uses:An acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RAR?and RAR. Antiacne; antipsoriatic. Used in treatment of photodamaged skin