2-(4-Methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethanone

Product Name:2-(4-Methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethanone
Synonyms:2-(4-methanesulfonyl-phenyl)-1-(6-methyl-pyridin-3-yl)-ethanone;
1-(6-methyl-3-pyridinyl)-2[4-(methylthio)phenyl]ethanone;
1-(6-methyl-3-pyridinyl)-2-[4-(methylsulfonyl)phenyl]ethanone;
1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]-ethanone;
CAS:247068-85-5
MF:C15H15NO3S
MW:221615-75-4
Type:Pharmaceutical Intermediates
Density:1.242g/cm3
Boiling Point:509.695ºC at 760 mmHg
Flash Point:262.054ºC
Refractive Index:1.573
Vapor Pressure:0mmHg at 25°C
Description:This compound is an impurity in the synthesis of Etoricoxib, a specific inhibitor of COX-2 .
Etoricoxib works by blocking the effect of a natural chemical called cyclo-oxygenase-2 (COX-2) enzyme. This enzyme helps to make other chemicals, called prostaglandins, in the body. Some prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX-2 enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased.
Anti-inflammatory painkillers like etoricoxib are also called non-steroidal anti-inflammatory drugs (NSAIDs), or sometimes just 'anti-inflammatories'. Etoricoxib eases pain and swelling (inflammation) in conditions like osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, and it may also be used for short periods of time in gout.